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Scatter plots of (a) grain size and sand wave height and (b) the velocity amplitude and the sand waves spatial frequency. The colors mark the three largest bins for this analysis. The spatial distribution of each of the bins is shown in the insets.
Scatter plots of (a) grain size and sand wave height and (b) the M2 velocity amplitude and the sand waves spatial frequency. The colors mark the three largest bins for this analysis. The spatial distribution of each of the bins is shown in the insets.

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b show a clear positive trend of increasing spatial sand wave frequencies and M 2 velocity amplitudes. Within the shown bins, the correlation is weakest for the data points in the south where velocity amplitudes are largest and increases for the bins with weaker tidal M 2 velocities northward in the main sand wave field.

Plotting the calculated correlations of the groups of points per square kilometer on their location in the map results in spatial representations of corrected correlations as indicators of the effect of environmental parameters in controlling sand wave shape characteristics as shown in Figure 7 . The sign of the correlations indicates the direction of the relation. Large absolute values indicate strong relations, and small absolute values indicate weak relations due to a large variability or small range of the environmental parameter within the bin.

Figure 7
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Environmental parameters in columns (a) median grain size, (b) water depth, (c) tidal velocity amplitude, (d) tidal peak velocity asymmetry, and (e) 99th percentile of significant surface wave height with correlations to sand wave shape characteristics in rows (1) height, (2) spatial frequency, and (3) asymmetry.
Environmental parameters in columns (a) median grain size, (b) water depth, (c) tidal M2 velocity amplitude, (d) tidal peak velocity asymmetry, and (e) 99th percentile of significant surface wave height with correlations to sand wave shape characteristics in rows (1) height, (2) spatial frequency, and (3) asymmetry.

In general, since all coefficients are less than |0.5| and vary substantially within the sand wave area, none of the sand wave characteristics show a consistent and strong correlation with any of the environmental parameters. Sand wave heights are only very weakly (−0.20 to 0.20) correlated to the tidal M 2 velocity amplitude throughout the sand wave fields. Correlations of sand wave heights to water depths are generally very weak but are moderately positive (>0.3) in several small sections near the coast. Sand wave heights are generally very weakly correlated to surface wave heights (−0.2 to 0.1); merely in the coastal area near Rotterdam, moderate and positive correlations are observed. Sand wave heights show the strongest and negative correlations with the residual current velocity in the north (−0.5 to −0.2). Furthermore, the correlations of sand wave heights to median grain sizes are moderate and predominantly positive and, as shown in Figure 6 a (see also Figure 2 ), are stronger for the smaller grain sizes (<350μm) in the northern part of the main sand wave field.

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Time

11 (Thursday) 9:00 am - 12 (Friday) 4:30 pm

Location

701 Gateway Boulevard, Suite 440, South San Francisco, CA 94080

Course Summary

Drug Development Immersion is a two-day, intensive course focused on the regulatory, commercial and scientific considerations required to bring a drug successfully to market. Discussion points feature both small molecule

Drug Development Immersion is a two-day, intensive course focused on the regulatory, commercial and scientific considerations required to bring a drug successfully to market. Discussion points feature both small molecule and biologic products. Post-approval commercial considerations and risk management are also discussed. Numerous personal accounts and war stories are used to illustrate the decision-making process companies use, giving participants a working knowledge of strategic development. Learn what it takes to get a molecule from the bench into the marketplace by an industry expert.

All course materials are handed out in the course. There is no pre-work required. Lunch will be provided.

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Dr. Gelfman is the Senior Director of Scientific Services at Ora, Inc., an ophthalmic contract research organization (CRO) providing preclinical, regulatory, and clinical trial services for companies worldwide. Her responsibilities in this role include the design and implementation of preclinical translational strategies and their integration into the clinical development process for the advancement of therapeutics to treat major unmet...

Contact Emily Sullivan at 410-377-4429 or at sullivan@biotechprimer.com

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All courses and products are final sale. No refunds, exchanges or transfers. If you cannot attend your purchased event, you may send someone in your place by notifying Emily Sullivan, Sullivan@BiotechPrimer.com, no later than one week before the start date of the class.

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BioImmersion

16 oct (oct 16) 9:00 am 18 (oct 18) 4:30 pm BioImmersion Chicago, IL 9:00 am - 4:30 pm (18) Schiff Hardin Offices233 S Wacker Dr, Chicago, IL 60606

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BioISI – BioSystems and Integrative Sciences Institute Faculdade de Ciências da Universidade de Lisboa Campo Grande, 1749-016 Lisboa PORTUGAL

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